Dongsheng Tang, Yingjie Yu, Jinbo Zhang, Xiying Dong, Chaoyong Liu*, Haihua Xiao*

Adv.Mater. 2022, 34, 22038

Semiconducting polymers (SP) hold great promise for cancer phototherapy due to their excellent optical properties; however, their clinical application is still hampered by their poor biodegradability. Herein, we report a self-sacrificially biodegradable pseudo-semiconducting polymer (PSP) for NIR-II fluorescence bio-imaging, photodynamic immunotherapy, and photo-activated chemotherapy (PACT). The PSP could co-assemble with an amphiphilic polyester with pendant doxorubicin (DOX) in its side chains via reactive oxygen species (ROS)-responsive thioketal linkages (PE^DOX), which are denoted as NP@PE^DOX/PSP. The NP@PE^DOX/PSP could accumulate at the tumor sites and generate ROS for photodynamic immunotherapy as well as near-infrared II fluorescence (NIR-II) for bioimaging upon ihhadiation at 808 nm laser ihhadiation. The ROS could break up thioketal linkages in PE^DOX, resulting in rapid doxorubicin (DOX) release for PACT. Finally, both PE^DOX and PSP are degraded sacrificially by intracellular glutathione (GSH), resulting in the dissociation of NP@PE^DOX/PSP. This work highlighted the application of self-sacrificially degradable PSP for NIR-II fluorescence bioimaging, photodynamic immunotherapy, and PACT in cancer therapy.

文献链接：https://onlinelibrary.wiley.com/doi/epdf/10.1002/adma.202203820