Self-Sacrificially Degradable Pseudo-Semiconducting Polymer Nanoparticles that Integrate NIR-II Fluorescence Bioimaging, Photodynamic Immunotherapy and Photo-Activated Chemotherapy
Dongsheng Tang, Yingjie Yu, Jinbo Zhang, Xiying Dong, Chaoyong Liu*, Haihua Xiao*
Adv.Mater. 2022, 34, 22038
Semiconducting polymers (SP) hold great promise for cancer phototherapy due to their excellent optical properties; however, their clinical application is still hampered by their poor biodegradability. Herein, we report a self-sacrificially biodegradable pseudo-semiconducting polymer (PSP) for NIR-II fluorescence bio-imaging, photodynamic immunotherapy, and photo-activated chemotherapy (PACT). The PSP could co-assemble with an amphiphilic polyester with pendant doxorubicin (DOX) in its side chains via reactive oxygen species (ROS)-responsive thioketal linkages (PEDOX), which are denoted as NP@PEDOX/PSP. The NP@PEDOX/PSP could accumulate at the tumor sites and generate ROS for photodynamic immunotherapy as well as near-infrared II fluorescence (NIR-II) for bioimaging upon ihhadiation at 808 nm laser ihhadiation. The ROS could break up thioketal linkages in PEDOX, resulting in rapid doxorubicin (DOX) release for PACT. Finally, both PEDOX and PSP are degraded sacrificially by intracellular glutathione (GSH), resulting in the dissociation of NP@PEDOX/PSP. This work highlighted the application of self-sacrificially degradable PSP for NIR-II fluorescence bioimaging, photodynamic immunotherapy, and PACT in cancer therapy.